Creatine is SAFE, the verdict is in! After decades of people claiming that creatine will wreck your kidneys, liver, & various other claims, a new study has put these myths to bed. In my latest episode of the Dr. Layne Norton Podcast, I go DEEP on the most comprehensive dataset to date: a brand new meta-analysis by Kreider et al. (2025) which reviewed 250+ studies, covering over 26,000 participants, some lasting more than a decade, and examined nearly 50 potential side effects. The verdict? Absolutely no evidence of harm. I broke down the full paper, the methods, and what this means for athletes and everyday lifters in the latest episode of the podcast. SPONSORS • Outwork Nutrition - Evidence-Based Supplements to Support Your Hard Work: https://outworknutrition.com • REPS Research Review: https://biolayne.com/reps LAYNE'S COMPANIES Carbon Diet Coach: https://joincarbon.com/podcast Outwork Nutrition: https://outworknutrition.com REPS Research Review: https://biolayne.com/reps Workout Builder: https://biolayne.com/workout-builder Team Biolayne: https://biolayne.com/online-coaching Physique Coaching Academy: https://physiquecoachingacademy.com FOLLOW LAYNE http://www.facebook.com/laynenorton http://www.twitter.com/biolayne http://www.instagram.com/biolayne TIMESTAMPS 0:00:00 - Intro 0:01:33 - Meta Analysis Overview 0:02:14 - Creatine is NOT a Steroid 0:03:10 - ATP 0:05:13 - Creatine from Body and Food 0:06:05 - Creatine Non-Responders 0:06:27 - Creatine Dose 0:07:10 - Creatine Benefits 0:10:18 - Outwork Nutrition 0:11:46 - Interesting Associations 0:13:48 - Safety Questions 0:15:03 - Importance of Placebo 0:17:05 - Study Methods 0:20:05 - Study Results 0:26:08 - REPS Research Review 0:26:57 - Hair Loss 0:29:04 - Creatine is Safe and Effective 0:30:54 - Types of Creatine 0:36:54 - Creatine for Kids 0:38:50 - Recommendations 0:39:39 - Outro SHOW NOTES https://biolayne.com/podcasts/dr-layne-norton-podcast/study-deep-dive-creatine-is-safe-episode-13