Natalie Yivgi-Ohana, a pioneering scientist whose passion for mitochondria unlocks new frontiers in longevity medicine. Our conversation truly blew my mind—Dr. Yivgi-Ohana brings decades of expertise to demystify these tiny, ancient powerhouses that fuel every cell in our bodies, impact our hormones, drive immunity, and, as it turns out, play a central role in how we age. Episode Timestamps: Welcome to the Longevity Podcast and today's focus on mitochondria... 00:00:00 Maternal inheritance and critical functions of mitochondria... 00:05:56 Mitochondria as energy producers and hormone regulators... 00:07:03 Aha moments: mitochondria control life, death, and disease... 00:08:55 Endosymbiotic theory: how mitochondria originated... 00:10:19 Chronic disease, aging, and the connection to mitochondria... 00:16:10 Substrate fuels: carbs, fats, and importance of metabolic flexibility... 00:20:18 Mitochondria's control over immune system and signaling... 00:26:39 Mitochondrial transfer: how cells share organelle "powerhouses"... 00:32:42 Groundbreaking therapy: transplanting mitochondria for rare diseases... 00:36:40 Expanding mitochondrial therapies to age-related diseases... 00:42:57 Aging in women: hormones, mitochondria, and inflection points... 00:51:00 Stem cell exhaustion and cellular renewal... 00:52:24 Biomarkers: ways to measure mitochondrial health... 01:03:11 Supplements, lifestyle, and emotional health for mitochondria... 01:15:47 Medication choices and minimizing mitochondrial toxicity... 01:24:04 Our Amazing Sponsors: O₃RACLE by Wizard Sciences — A daily ozonated oil capsule designed to support immune balance, cellular communication, and antioxidant production without clinics, machines, or complicated routines; learn more at wizardsciences.com and use code NAT15 for 15% off. Magnesium Breakthrough by BIOptimizers — A full-spectrum magnesium supplement combining seven highly absorbable forms to support sleep, stress, muscle recovery, and nervous system balance in one nightly habit. Save 15% at bioptimizers.com/bionat with code BIONAT Vitali - combines pharmaceutical-grade copper peptides with zero-age exosomes to support clearer cellular signaling and long-term skin resilience, working with your biology instead of forcing change. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode