In this episode, Dr. Robert Sege and Dr. Baraka Floyd are joined by Dr. Nadine Burke Harris, California's first-ever Surgeon General. The conversation explores the profound impact of adverse childhood experiences (ACEs) and toxic stress, alongside the biological healing power of positive childhood experiences (PCEs). Through a compelling patient story, Dr. Burke Harris illustrates how buffering care—like child-parent psychotherapy—can reverse the effects of trauma and promote healthy growth. The hosts also discuss the importance of recognizing discrimination as a risk factor for toxic stress and emphasize that positive childhood experiences are essential for all children. For more on the HOPE framework, visit positiveexperience.org.