What if the real lever for lasting weight loss isn’t calories, but hunger itself? We sit down with Dr. Jason Fung to unpack why willpower-based diets fail and how hormones like insulin, cortisol, GLP-1, and sympathetic tone quietly set your “fat thermostat.” Instead of fighting biology, we explore how to work with it—lowering insulin, raising satiety, and removing the triggers that keep appetite stuck in overdrive. We dig into the three types of hunger that shape daily choices: homeostatic (physiological signals like ghrelin and leptin), hedonic (reward and emotion), and conditioned (learned cues from cars, screens, and social settings). Jason explains how ultra-processed foods exploit these systems by maximizing pleasure and minimizing fullness, why sleep and stress can spike cravings through cortisol, and how fasting strategically restores access to stored energy. We also discuss the difference between visceral and subcutaneous fat, why some people appear “skinny fat,” and how testing insulin, A1C, and C‑peptide gives a truer metabolic picture than BMI alone. From the failures of low-fat, calorie-counting eras to the surprising benefits seen with GLP-1 agonists, the throughline is clear: control hunger, and calories take care of themselves. You’ll leave with three golden rules to start today—ditch ultra-processed foods, use fasting windows to lower insulin, and build a supportive circle that normalizes real food. It’s a humane, science-driven framework that helps you stop battling your body and start resetting your internal settings. If this conversation helped reframe your approach to weight and health, follow the show, share it with a friend, and leave a quick review to help others find it. https://www.doctorjasonfung.com/ Continue this conversation on SubStack: https://robertlufkinmd.substack.com Get 120 Biomarkers for $99 and CT Calcium scans anywhere in the US. https://www.vitalsvault.com/ Lies I Taught In Medical School: Free sample chapter- https://www.robertlufkinmd.com/lies/ Web: https://robertlufkinmd.com/ X: https://x.com/robertlufkinmd Youtube: https://www.youtube.com/robertLufkinm d Instagram: https://www.instagram.com/robertlufkinmd/ LinkedIn: https://www.linkedin.com/in/robertlufkinmd/ TikTok: https://www.tiktok.com/@robertlufkin Threads: https://www.threads.net/@robertlufkinmd Facebook: https://www.facebook.com/robertlufkinmd Bluesky:...