A ketogenic diet put his ulcerative colitis into complete remission — off all medications, confirmed on colonoscopy. Dr. Nick Norwitz (PhD Oxford, MD Harvard) explains why evidence-based care isn't always optimal care, how keto rewires the gut and brain, and why GLP-1 drugs should catalyze lifestyle change, not replace it. CHAPTERS: 0:00 - The most remarkable thing about my story is it's not unique 1:14 - Welcome Nick Norwitz — Oxford PhD, Harvard MD 2:02 - Ulcerative colitis, desperation, and keto remission 5:34 - What medical school doesn't teach 8:05 - Why evidence-based care ≠ optimal care 15:53 - The carnivore-ketogenic IBD case series (10 patients) 18:50 - Fiber elimination in pediatric Crohn's — 60–85% remission 20:00 - Keto for depression: Ohio State trial — 69–71% reduction 23:49 - Seed oils: the nuanced truth 29:32 - Ketones and neurodegenerative disease 32:52 - Autophagy, lateral habenula, and depression 36:16 - Sonnenburg 2021: fermented foods beat fiber for inflammation 37:20 - GLP-1 agonists: good tool, poor deployment 43:29 - Statins slash GLP-1 by ~50% (Cell Metabolism, 2024) 48:57 - Closing REFERENCES: Carnivore-Keto for IBD (Norwitz et al., Frontiers, 2024): PMC11409203 Keto for Depression (Ohio State, 2025): PMC12420795 Fermented Foods vs Fiber (Sonnenburg, Cell, 2021): Stanford News Statins Slash GLP-1 (Cell Metabolism, 2024): pubmed/38325336 Autophagy + Depression (Nature, 2025): Nature GUEST: Nick Norwitz, PhD MD HOST: Dr. Robert Lufkin MD | robertlufkinmd.com New episodes every Tuesday & Thursday. Subscribe so you don't miss one. Continue this conversation on Substack: https://robertlufkinmd.substack.com Lies I Taught In Medical School — Free sample chapter: https://www.robertlufkinmd.com/lies/ Web: https://www.robertlufkinmd.com YouTube: https://www.youtube.com/robertlufkinm d X: https://x.com/robertlufkinmd Instagram: https://www.instagram.com/robertlufkinmd/ TikTok: https://www.tiktok.com/@robertlufkin LinkedIn: https://www.linkedin.com/in/robertlufkinmd/