In 1969, Harvard pathologist Kilmer McCully discovered elevated homocysteine causes arterial damage and heart disease. He was forced out of Harvard. The Framingham Heart Study confirmed him. Then the AHA buried it anyway. CHAPTERS: 00:00 - McCully discovery and suppression 01:20 - Part 1: What homocysteine does to arteries (6 mechanisms) 03:25 - Part 2: The evidence they ignored 03:40 - Every 5 umol/L: 20-30% higher CAD risk, 60% stroke risk 04:50 - Alzheimers risk +48% (meta-analysis, 7,474 subjects) 06:10 - Part 3: Why it was abandoned (VISP, NORVIT, HOPE-2) 07:50 - Cochrane: B vitamins reduced stroke 10% 08:20 - CSPPT: folic acid reduced stroke 21% to 73% 09:10 - Part 4: Your brain on homocysteine 09:25 - VITACOG: brain atrophy 30% slower, 53% in high-Hcy group 10:05 - PNAS 2013: 7x less hippocampal atrophy 11:00 - Part 5: What to do 11:10 - Test fasting homocysteine: target under 8-10 umol 11:40 - Methylfolate, methylcobalamin, P5P REFERENCES: Homocysteine CVD Risk 2025: PMC12564181 VITACOG Trial (PLoS ONE, 2010): PMC2935890 VITACOG 2025 Metabolomics: PubMed 40684250 Homocysteine Alzheimers Risk: PMC12280720 Cochrane B Vitamins Stroke: Cochrane CSPPT Folic Acid: ACC JAMA 2010 Meta-Analysis: JAMA HOST: Dr. Robert Lufkin MD | robertlufkinmd.com New episodes every Tuesday & Thursday. Subscribe so you don't miss one. Continue this conversation on Substack: https://robertlufkinmd.substack.com Lies I Taught In Medical School — Free sample chapter: https://www.robertlufkinmd.com/lies/ Web: https://www.robertlufkinmd.com YouTube: https://www.youtube.com/robertlufkinm d X: https://x.com/robertlufkinmd Instagram: https://www.instagram.com/robertlufkinmd/ TikTok: https://www.tiktok.com/@robertlufkin LinkedIn: https://www.linkedin.com/in/robertlufkinmd/