What if an AI could run centuries of aging experiments in a year? Dr. Daniel Ives, CEO of Shift Bioscience, explains how his team used a virtual cell to discover SB000 — a single gene that matches Yamanaka factor rejuvenation without cancer risk. CHAPTERS: 00:00 — Centuries of experiments in a year 02:03 — Daniel's journey: physics → Aubrey de Grey 10:08 — The epigenetic clock breakthrough 12:09 — The 13 mitochondrial genes 20:09 — Yamanaka factors (OSKM) explained 22:10 — Partial reprogramming: the weekend analogy 24:11 — The cancer risk problem 26:11 — AI virtual cell: how it works 32:12 — AI-driven dark labs 40:16 — Single-gene interventions 42:17 — Shift's discovery: genes that reverse aging 50:19 — Animal testing begins 62:20 — Hearing loss: the unexpected aging connection 66:21 — Rapamycin reverses hearing loss in animals 78:25 — N=1 medicine and wearables 84:26 — Closing REFERENCES: Shift Bioscience: shiftbioscience.com Partial Reprogramming (Nature Comms, 2024): Nature Epigenetic Clock (Frontiers in Aging, 2024): Frontiers GUEST: Dr. Daniel Ives, PhD — CEO, Shift Bioscience, Cambridge UK HOST: Dr. Robert Lufkin MD | robertlufkinmd.com New episodes every Tuesday & Thursday. Subscribe so you don't miss one. Continue this conversation on Substack: https://robertlufkinmd.substack.com Lies I Taught In Medical School — Free sample chapter: https://www.robertlufkinmd.com/lies/ Web: https://www.robertlufkinmd.com YouTube: https://www.youtube.com/robertlufkinm d X: https://x.com/robertlufkinmd Instagram: https://www.instagram.com/robertlufkinmd/ TikTok: https://www.tiktok.com/@robertlufkin LinkedIn: https://www.linkedin.com/in/robertlufkinmd/