The future of IBD medicine - Dr. Yasmin Mohseni, CAR T-cell Therapy and beyond

Send a text We are so excited to have Dr. Yasmin Mohseni back to to talk about the latest advances in the world of immunology! We discuss the recent Nobel Prize awarded for research on regulatory T cells (Tregs) and how they help keep inflammation and autoimmunity in check. We talk about the complexities of autoimmune diseases, particularly Inflammatory Bowel Disease (IBD), and why Tregs play such a big role in keeping the immune system balanced. Dr. Mohseni walks us through some of the most innovative treatments on the horizon, from cell therapies to CAR T-cell approaches, and even how AI might shape the future of medicine. We wrap things up on a hopeful note, looking ahead at where autoimmune treatments are going and why ongoing research matters more than ever. Dr. Yasmin Mohseni, PhD is an immunologist with 6+ years of experience in the cell and gene therapy biotech space, specializing in immunotherapy for cancer and immunoregulation. Dr Mohseni earned her PhD in Immunotherapy from King’s College London, where she focused on using engineered regulatory T cells (Tregs) to promote immune tolerance in solid organ transplantation with applications to autoimmunity. She began her industry journey at Quell Therapeutics, advancing Treg-based therapies, and now works at A2 Biotherapeutics in the cancer immunotherapy space, developing therapies for solid tumors. Find Dr Yas here: https://www.instagram.com/doctor.yas_/ Takeaways- - Tregs are crucial for suppressing inflammation in the immune system. - The Nobel Prize recognition highlights the importance of Tregs in immunology. - Autoimmunity involves a complex interplay of genetic and environmental factors. - Tregs can be dysfunctional in autoimmune diseases, leading to chronic inflammation. - Cell therapy, including CAR T-cells, shows promise for treating autoimmune diseases. - AI is revolutionizing target discovery in immunology and personalized medicine. - The future of autoimmune treatments is hopeful, with ongoing research and innovation. - Understanding the mechanisms of Tregs can lead to better therapeutic strategies. - The balance of immune responses is critical in managing autoimmune diseases. Chapters- 00:00- Introduction and Personal Updates 03:40- Nobel Prize in Immunology: Tregs and Their Significance 10:34- Understanding Autoimmunity and Inflammatory Bowel Disease (IBD) 16:12- The Role of Tregs in Autoimmunity 21:49- Exploring Cell Therapy and CAR T-Cell Approaches 27:26- Future of Autoimmunity Treatments and AI in Medicine 46:36- Conclusion and Future Perspectives Follow us on instagram @crohns_and_colitis_dietitians Follow us on youtube @thecrohnscolitisdietitians We love helping provide quality content on IBD nutrition and making it more accessible to all through our podcast, instagram and youtube channel. Creating the resources we provide comes at a significant cost to us. We dream of a day where we can provide even more free education, guidance and support to those with IBD like us. We need your support to do this. You can help us by liking episodes, sharing them on your social media, subscribing to you tube and telling others about us (your doctors, friends, family, forums/reddit etc). Can you do this for us? In return, I promise to continually level up what we do here. 💜 Ashley