Full Show Notes: https://bengreenfieldlife.com/nadplus In this fascinating episode, Dr. Nichola Conlon, molecular biologist and founder of Nuchido, breaks down what NAD actually is, what it does inside your cells, and why most popular strategies for boosting it, including NAD IVs, patches, and high-dose NR or NMN, may be fundamentally flawed based on molecular biology. You’ll discover why NAD declines by half every 20 years, why the NAMPT enzyme and not a shortage of raw material is the real bottleneck, and why flooding the body with precursors without fixing the salvage pathway can actually strain your methylation pathways rather than raise NAD. You’ll also explore how inflammation through the cluster of differentiation 38 (CD38) enzyme silently drains NAD faster than almost anything else, what a gold standard double-blind placebo-controlled crossover clinical trial on Nuchido TIME+ actually showed, and why NAD sits at the intersection of energy production, cellular repair, sleep, skin health, and biological aging. Dr. Nichola Conlon (BSc, MRes, PhD) specializes in cellular aging. After a career in drug development, Dr. Nichola founded Nuchido, driven by her belief that cutting-edge science should not lie hidden. At Nuchido, Dr. Nichola’s work focuses on delivering disruptive innovation in the field of anti-aging, rejuvenation, and healthspan. It has led to the development of Nuchido TIME+, a dietary supplement clinically proven to boost NAD+ and reverse biological age. Unlike standard precursors such as NMN or NR, Nuchido TIME+ uses a systems-based approach to target the root causes of NAD+ decline. 👉 You can use code BEN20 to save 20% off your first purchase of Nuchido TIME+ here. Episode Sponsors Timeline: Give your cells new life with high-performance products powered by Mitopure, Timeline's powerful ingredient that unlocks a precise dose of the rare Urolithin A molecule and promotes healthy aging. Mitopure now starts at $79, when you go to timeline.com/BEN. Young Goose: To experience the transformative power of Young Goose's cutting-edge skincare products, visit younggoose.com and use code BGF10 at checkout to enjoy a 10% discount on your order. Manukora: You haven’t tasted or seen honey like this before, so indulge and try some honey with superpowers from Manukora. If you head to manukora.com/ben or use code BEN, you’ll automatically get $25 off your Starter Kit. Qualia Stem Cell: Qualia Stem Cell is a science-backed supplement designed to support your body’s natural repair system by enhancing stem cell function, helping you recover, renew, and maintain healthy tissues as you age. Taken just four days per month and formulated with premium, clinically supported ingredients, it’s an easy way to support long-term healing and vitality. MTE: MTE is a caffeine-free daily drink mix with adaptogens, nootropics, and superfoods for clean energy, sharp focus, and balanced mood, without the crash. Boost your wellness at a systemic level with MTE's 13 healthy ingredients.