Discover the latest science behind fasting and innovative fasting alternatives in this episode with Dr. Chris Rhodes, nutritional biochemist. Learn about the anti-inflammatory and longevity benefits of a 36-hour fast, and how Mimio, a fasting supplement, can help you access fasting’s advantages without skipping meals. With special insights on women’s health—including hormones, muscle preservation, and metabolic changes—this is essential listening for anyone interested in optimizing wellness, especially women navigating midlife. Curious to try Mimio for yourself? Episode Overview (timestamps are approximate): (0:00) Intro/Teaser (4:00) The Biology of Fasting: What's Actually Happening (12:00) Fasting Timelines: 16:8 vs 24hr vs 36hr (16:00) The 36-Hour Metabolic Signature (21:00) NAD, Estrogen, and Women in Midlife (26:00) Cortisol, HPA Axis, and Female Sensitivity (30:00) Thyroid Suppression During Fasting (34:00) Muscle and Bone Preservation Strategies (43:00) The Four Fasting-Mimetic Molecules (54:00) Fasting Benefits Without Fasting (1:03:00) Clinical Study Results: 2.5 Years Younger (1:07:00) Dosing and Best Practices (1:12:00) BONUS: After-Party with Dr. Stephanie Resources mentioned in this episode can be found at https://drstephanieestima.com/podcasts/ep445/ We couldn’t do it without our sponsors: BON CHARGE - Achieve glowing skin, gain more energy, and uplevel your recovery practice with a suite of red light products. TROSCRIPTIONS - There’s a completely new way to optimize your health. Give it a try at https://troscriptions.com/BETTER or enter BETTER at checkout for 10% off your first order. BIOPTIMIZERS - Your digestion can take a hit in midlife, but you don't have to suffer. Learn how enzymes can help at https://bioptimizers.com/better and use code BETTER to get 10% off your order. MASA - MASA’s chips contain just three ingredients: organic nixtamalized corn, sea salt, and 100% grass-fed beef tallow. That's it. Ready to give MASA (or Vandy) a try? Use code BETTER for 25% off your first order at https://masachips.com/BETTER LMNT - Rehydrate with the perfect mix of sodium, potassium, and magnesium. **************************** P.S. When you're ready, here are two ways Dr. Stephanie can help you: Subscribe: The Mini Pause — My weekly newsletter packed with the most actionable, evidence-based tools for women 40+ to thrive in midlife. Build Muscle: LIFT — My progressive strength training program designed for women in midlife. Form-focused, joint-friendly, and built for real results. Hosted by Simplecast, an AdsWizz company.